07775 925762
Petroleum Distributors to Pay $2.5 Million to Settle Clean Air Act Allegations of Illegal Mixing and Distribution of Gasoline in Colorado and Nebraska
Three Colorado-based gasoline distributors have agreed to pay $2.5 million to resolve claims that they illegally mixed and distributed more than one million gallons of gasoline that did not meet Clean Air Act emissions and fuel quality requirements.
Peter V'landys's hyper-aggressive approach to restarting the NRL could end in boom or bust
Flattering comparisons with other leading sports officials have also helped elevate the ARL chairman's current status as the can-do man of Australian sport, but as Richard Hinds asks, is he about to make a huge mistake?
Peter MacKay suggests Magnitsky Act should be used against China
Conservative leadership hopeful Peter MacKay is calling for use of the Magnitsky Act if specific individuals in China can be identified as having suppressed information related to COVID-19.
Petrol stations accused of gouging as some Queenslanders pay 75 per cent more
While the price of petrol falls to the lowest point in a generation in Brisbane, service stations are charging 30 per cent more in north Queensland and 75 per cent more in Mt Isa, with a federal MP raising accusations of collusion.
Petrol stations taking 'too long to pass on savings', ACCC says
At a time when the economy is suffering the ACCC is calling on the petrol retailers to pass on the full benefit of the falling oil price to motorists.
Peter Bonetti was a goalkeeping great but also humble and friendly – Chris Woods remembers the Chelsea legend
The death on Sunday of Peter Bonetti at the age of 78 after a long illness has seen endless tributes paid to the Chelsea goalkeeping great.
Peter Bonetti: Ron 'Chopper' Harris pays tribute to 'proper gentleman' who never raised his voice
Chelsea legend Ron Harris has paid tribute to former goalkeeper Peter Bonetti, the 'proper gentleman' and 'fitness fanatic' who led by example in west London.
Peter Bonetti dead: Former Chelsea and England goalkeeper 'The Cat' passes away, aged 78
Bonetti was part of the England squad that won the 1966 World Cup
Peter Bonetti: Tributes paid to Chelsea goalkeeper as Petr Cech hails 'The Cat' a club 'legend'
Bonetti, dubbed 'The Cat', died at the age of 78 on Sunday
Pete Davidson received weed delivery from complete stranger
In a separate Instagram Live chat with Apatow, the actor explained the bag contained "a couple weeks' worth" of marijuana, which he gave to a friend.
Peter Kay asks fans to help remake Amarillo video for Big Night In charity special
Kay's original Amarillo video featured an eclectic line-up of celebrity cameos
Pete Davidson fan delivered drugs to comedian's mother's house during lockdown
Davidson is currently quarantining in his mother's basement
Peter Kay worries fans after first TV appearance in two years: 'He doesn't look well'
Beloved comedian praised for 'down to earth' donation message
Peter MacKay suggests Magnitsky Act should be used against China for COVID-19
Conservative leadership hopeful Peter MacKay is calling for use of the Magnitsky Act if specific individuals in China can be identified as having suppressed information related to COVID-19.
Pete Davidson needs to sort his life out in first trailer for 'The King of Staten Island'
From 'Saturday Night Live' to the big screen, Pete Davidson could become Judd Apatow's next comedy megastar.
Peter Hook pays tribute to Florian Schneider
Florian Schneider passed away aged 73 following a short battle with cancer.
Pet food can contain drug-resistant bacteria that may pass to humans
Some dogs and cats may be passing gut microbes to their owners that withstand last-resort antibiotics, which can be needed to fight off pneumonia from a coronavirus infection
RPG Cast – Episode 537: “Shady Turnip Deal”
Peter, Kelley, Chris, and Anna Marie are joined by Alice this week; while she didn’t deliver any missiles, large robots may be a part of the podcast in unexpected ways! We discuss cheating on the stalk market, the news of the week, and your feedback. Now to wait for our copies of Persona 5 Royal to arrive...hurry up already!
Pets May Help Parents of Kids With Autism Fight Stress
Title: Pets May Help Parents of Kids With Autism Fight Stress
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM
Pet Food Recall Widens Again on New Threat
Title: Pet Food Recall Widens Again on New Threat
Category: Health News
Created: 5/4/2007 2:00:00 AM
Last Editorial Review: 5/4/2007 12:00:00 AM
Pet food can contain drug-resistant bacteria that may pass to humans
Some dogs and cats may be passing gut microbes to their owners that withstand last-resort antibiotics, which can be needed to fight off pneumonia from a coronavirus infection
Petrochem Industry to Invest 10 Tril. Won in Daesan Industrial Complex
The Daesan petrochemical industrial zone in Seosan, South Chungcheong Province, will transform into an advanced chemical industrial complex. The nation's major petrochemical companies may invest up to 10 trillion won in this area. On September 14, S-Oil, Lotte Chemical, Hanwha Total, South Chungcheong provincial government, and Seosan city gathered in Lotte World Tower and signed a memorandum to create a Daesan specialized industrial complex. Currently the area is home to large petrochemical ...
Pets stranded by travel shutdown
When Guy Nizan flew to Israel with his wife and daughter for a family emergency in March, Gula — their six-year-old German shepherd mix — stayed behind in New York with a pet sitter.
Pet Adoption: Save an Animal’s Life
At our heart, Zoetis is about caring for animals – and some animals need a little more care than others. Adopting an animal from a shelter has many advantages.
Life-changing moment
Peter* from MAP Australia has a Muslim friend who attended a church camp. His friend has never been the same since.
Pete Rose had bats corked in '84, former Expos groundskeeper says
A former groundskeeper for the Expos recently told the Montreal Gazette that Pete Rose, who played less than a full season with the team, routinely had an Olympic Stadium staffer cork his bats in 1984.
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
Peter Klivenyi
Jan 1, 2000; 20:1-7
Cellular
{Delta}9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism
Peter M. Zygmunt
Jun 1, 2002; 22:4720-4727
Behavioral
Petroleum Feeds Patriarchy
Climate change. Pollution. Financial expense. Our gas-guzzling ways have long been associated with a variety of problems, but disturbing evidence now points to a new dimension of our love affair with petroleum: Oil consumption and high oil prices hurt the political, social and economic development...
Petrobras sells Chevron $350M Texas plant bought for $1.2B
Chevron bought a Houston refinery for $350 million from Petrobras that had cost the Brazilian state oil company over $1.2 billion little over a decade earlier.
Petrobras preempts three pre-salt areas ahead of sixth auction
Petrobras wants to exercise pre-emption rights for three areas ahead of the sixth bidding round of pre-salt offshore oil areas to be held later this year.
Influence of Dietary Protein Intake on Whole-Body Protein Turnover in Humans
Peter J Garlick
Dec 1, 1991; 14:1189-1198
Diet and Diabetes
PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) has traditionally been characterized by a complete destruction of β-cell mass (BCM); however, there is growing evidence of possible residual BCM present in T1DM. Given the absence of in vivo tools to measure BCM, routine clinical measures of β-cell function (e.g., C-peptide release) may not reflect BCM. We previously demonstrated the potential utility of PET imaging with the dopamine D2 and D3 receptor agonist 3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol (11C-(+)-PHNO) to differentiate between healthy control (HC) and T1DM individuals. Methods: Sixteen individuals participated (10 men, 6 women; 9 HCs, 7 T1DMs). The average duration of diabetes was 18 ± 6 y (range, 14–30 y). Individuals underwent PET/CT scanning with a 120-min dynamic PET scan centered on the pancreas. One- and 2-tissue-compartment models were used to estimate pancreas and spleen distribution volume. Reference region approaches (spleen as reference) were also investigated. Quantitative PET measures were correlated with clinical outcome measures. Immunohistochemistry was performed to examine colocalization of dopamine receptors with endocrine hormones in HC and T1DM pancreatic tissue. Results: C-peptide release was not detectable in any T1DM individuals, whereas proinsulin was detectable in 3 of 5 T1DM individuals. Pancreas SUV ratio minus 1 (SUVR-1) (20–30 min; spleen as reference region) demonstrated a statistically significant reduction (–36.2%) in radioligand binding (HCs, 5.6; T1DMs, 3.6; P = 0.03). Age at diagnosis correlated significantly with pancreas SUVR-1 (20–30 min) (R2 = 0.67, P = 0.025). Duration of diabetes did not significantly correlate with pancreas SUVR-1 (20–30 min) (R2 = 0.36, P = 0.16). Mean acute C-peptide response to arginine at maximal glycemic potentiation did not significantly correlate with SUVR-1 (20–30 min) (R2 = 0.57, P = 0.05), nor did mean baseline proinsulin (R2 = 0.45, P = 0.10). Immunohistochemistry demonstrated colocalization of dopamine D3 receptor and dopamine D2 receptor in HCs. No colocalization of the dopamine D3 receptor or dopamine D2 receptor was seen with somatostatin, glucagon, or polypeptide Y. In a separate T1DM individual, no immunostaining was seen with dopamine D3 receptor, dopamine D2 receptor, or insulin antibodies, suggesting that loss of endocrine dopamine D3 receptor and dopamine D2 receptor expression accompanies loss of β-cell functional insulin secretory capacity. Conclusion: Thirty-minute scan durations and SUVR-1 provide quantitative outcome measures for 11C-(+)-PHNO, a dopamine D3 receptor–preferring agonist PET radioligand, to differentiate BCM in T1DM and HCs.
Peter Phillips | Protecting our people is priority in the COVID-19 fight
The national priority at this time must be the protection of the Jamaican people against the onset of COVID-19. This has to be done by striking the balance between implementing protective public-health measures and providing a supporting economic...
Petro-RMB? The oil trade and the internationalization of the renminbi
4 September 2019 , Volume 95, Number 5
In this article, we examine China's promotion of the renminbi (RMB) in international oil trade and explore its implications for the international currency system in the short and the long term. The article traces the rise of the RMB in international oil trade in recent years and provides an analysis of its impact on the internationalization of the Chinese currency. We argue that despite the increasing use of the yuan in oil trade in recent years, in the short term it is highly unlikely that a petro-RMB system will emerge to rival the petrodollar system. Unlike the petrodollar, which combines the qualities of a master currency, a top currency and a negotiated currency, China lacks the economic leadership and the political and geopolitical leverages to make the RMB a major petrocurrency. Although the emergence of the RMB-denominated Shanghai oil futures is an important development, the absence of highly developed financial markets and a strong legal system in China hinders its potential. In the long run, the RMB may take on a more prominent role in the international oil trade as China's weight as an oil importer rises. More importantly, the overuse of financial sanctions by the US government has begun to undermine the role of the dollar within and beyond the oil trade. In addition, the rise of alternative energy sources will diminish the centrality of oil in the world economy, thus reducing the significance of petrocurrencies—whether the dollar or the RMB—in shaping the international currency system.
PET imaging quantifying 68Ga-PSMA-11 uptake in metastatic colorectal cancer
At diagnosis 22% of colorectal cancer (CRC) patients have metastases and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (177Lu)-PSMA-617 is employed to treat metastatic prostate cancer (PC). 177Lu-PSMA-617 targets Prostate Specific Membrane Antigen (PSMA) a cell surface protein enriched in PC and the neovasculature of other solid tumors including CRC. We performed gallium-68 (68Ga)-PSMA-11 PET-CT imaging of ten metastatic CRC patients to assess metastasis avidity. Eight patients had lesions lacking avidity and two had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for 177Lu-PSMA-617 PRRT.
PET imaging of phosphodiesterase-4 identifies affected dysplastic bone in McCune-Albright syndrome, a genetic mosaic disorder
McCune-Albright syndrome (MAS) is a mosaic disorder arising from gain-of-function mutations in the GNAS gene, which encodes the 3', 5'-cyclic adenosine monophosphate (cAMP) pathway-associated G-protein, Gsα. Clinical manifestations of MAS in a given individual, including fibrous dysplasia, are determined by the timing and location of the GNAS mutation during embryogenesis, the tissues involved, and the role of Gsα in the affected tissues. The Gsα mutation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodiesterase type 4 (PDE4), which catalyzes the hydrolysis of cAMP. Increased cAMP levels have been found in vitro in both animal models of fibrous dysplasia and in cultured cells from individuals with MAS, but not in humans with fibrous dysplasia. Positron emission tomography (PET) imaging of PDE4 with 11C-(R)-rolipram has been used successfully to study the in vivo activity of the cAMP cascade. To date, it remains unknown whether fibrous dysplasia and other symptoms of MAS, including neuropsychiatric impairments, are associated with increased PDE4 activity in humans. Methods: 11C-(R)-rolipram whole-body and brain PET scans were performed in six individuals with MAS (three for brain scans and six for whole-body scans) and nine healthy controls (seven for brain scans and six for whole-body scans). Results: 11C-(R)-rolipram binding correlated with known locations of fibrous dysplasia in the periphery of individuals with MAS; no uptake was observed in the bones of healthy controls. In peripheral organs and the brain, no difference in 11C-(R)-rolipram uptake was noted between participants with MAS and healthy controls. Conclusion: This study is the first to find evidence for increased cAMP activity in areas of fibrous dysplasia in vivo. No differences in brain uptake between MAS participants and controls were detected, which could be due to several reasons, including the limited anatomic resolution of PET. Nevertheless, the results confirm the usefulness of PET scans with 11C-(R)-rolipram to indirectly measure increased cAMP pathway activation in human disease.
PET/CT imaging with a 18F-labeled galactodendritic unit in a galectin-1 overexpressing orthotopic bladder cancer model
Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with fluorine-18 – 18F-labeled galactodendritic unit 4 – and examined its potential in imaging urothelial malignancies. Methods: The 18F-labeled 1st generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in galectin-expressing UMUC3 orthotopic BCa model to determine the ability of 18F-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of 18F-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1 overexpressing UMUC3 orthotopic tumors when imaged with PET. The 18F-labeled galactodendritic unit 4 was not found to accumulate in non-tumor murine bladders. Conclusion: The 18F-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1 overexpressing bladder tumors.
PET/MRI versus PET/CT in whole-body staging: results from a unicenter observational study in 1003 subsequent examinations
Purpose: To investigate differences between positron emission tomography/magnetic resonance imaging (PET/MRI) and PET/computed tomography (PET/CT) in lesion detection and classification in oncological whole-body examinations and to investigate radiation exposure differences between both modalities. Material and Methods: In this prospective, single-center, observational study 1003 oncological examinations (918 patients, mean age 57.8±14.4y) were included. Patients underwent PET/CT and subsequent PET/MRI (149.8±49.7min after tracer administration). Examinations were reviewed by radiologists and nuclear medicine physicians in consensus. Additional findings, characterization of indetermiante findings in PETCT, missed findings in PET/MRI including their clinical relevance and effective dose of both modalities were investigated. McNemar’s test was used to compare lesion detection between both hybrid imaging modalities (p<0.001 indicating statistical significance). Results: Additional information in PET/MRI was reported in 26.3% (264/1003) of examinations compared to PET/CT (p<0.001). Of these, additional malignant findings were detected in 5.3% (53/1003), leading to a change in TNM-staging in 2.9% (29/1003) due to PET/MRI. Definite lesion classification of indeterminate PET/CT findings was possible in 11.1% (111/1003) with PET/MRI. In 2.9% (29/1003), lesions detected in PET/CT were not visible in PET/MRI. Malignant lesions were missed in 1.2% (12/1003) by PET/MRI leading to a change in TNM-staging in 0.5% (5/1003). The estimated mean effective-dose for whole-body PET/CT amounted to 17.6±8.7mSv in comparison to 3.6±1.4mSv in PET/MRI, resulting in a potential dose reduction of 79.6% (p<0.001). Conclusion: PET/MRI improves lesion detection and potentially reduces additional examinations in tumor staging. Especially younger patients may benefit from the clinically relevant dose reduction of PET/MRI compared to PET/CT.
Peter Watkins
Associate Fellow, International Security Programme
Biography
Peter Watkins became an associate fellow for Chatham House in June 2019. Before that, from 2014 to 2018, he was Director General (DG) in the UK Ministry of Defence (MoD) responsible for strategic defence policy, including key multilateral and bilateral relationships (such as NATO), nuclear, cyber, space and prosperity (latterly this post was known as the DG Strategy and International).
Previously he served as DG of the Defence Academy, Director of Operational Policy, Director responsible for the UK share of the multinational Typhoon combat aircraft programme and as Defence Counsellor in the UK Embassy in Berlin.
He is a frequent participant in conferences on defence and security in the UK and overseas.
He was awarded the CB (2019) and CBE (2004) for services to defence. He has an MA from Cambridge University.
Areas of expertise
- European security
- Deterrence policy
- Nuclear policy
- Stabilisation and peacekeeping
- International armaments cooperation
Past experience
| 2006-07 | Fellow, Weatherhead Center for International Affairs, Harvard University |
| 1993-94 | Senior course member, NATO Defense College |
Watch Peter Kay’s Car Share Online | Season 1 Full Episodes Video Streaming & Torrent Search
Peter Kay’s Car Share Synopsis Peter Kay’s Car Share is a situation comedy television series produced by BBC One that premiered in April of 2015. Peter Kay’s Car Share follows the story of John (played by Peter Kay), an assistant manager in a supermarket and his co-worker and promotions rep Kayleigh (played by Sian Gibson). […]
Pete Buttigieg plays the didgeridoo and other unexpected musical talents of the 2020 candidates
You know about Beto O'Rourke on the guitar, of course, but what about Bernie Sanders's spoken-word album?
Pete Buttigieg may have stars such as Ellen DeGeneres and Jennifer Aniston to thank for his fundraising haul
The small town mayor is raking in some cash from A-list donors.
Pete Buttigieg, comic-book hero: How one company is bringing the Democratic candidates’ stories to life in pictures
TidalWave Productions is releasing Buttigieg and Bloomberg comic books to sit alongside its Warren biography.
Pete Buttigieg tweets demand for 'transparent investigation' of Dreasjon Reed shooting
Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.
Pet Airways 宠物专用航空公司
Cats and dogs, get ready for take off! The world's first airline for pets has been launched in the United States.
Pete Buttigieg tweets demand for 'transparent investigation' of Dreasjon Reed shooting
Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.
petroleum
Marathon Oil Corporation designs, delivers and maintains strategic and complex assets for its customers across the global energy and related sectors. Marathon Oil Corporation career is not just a job. It's an extraordinary opportunity to help create the future of energy. No matter what type of
